5-Amino-1MQ (Capsules)
NNMT Inhibitor
CAS: 42464-96-0
Formula: C10H12N2
M.W.: 160.2192 g/mol
Purity: 99%+ HPLC Verified
Ref No.: 5-A-0050TA
For Research Use Only (RUO)
Not for human or veterinary use.
5-Amino-1MQ (Capsules)
Category
GLP / Metabolic
CAS Number
42464-96-0
Form Factor
Capsules
In stock, ready to ship
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Products are shipped in freeze dried powder form.
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism and fat storage regulation. By blocking NNMT activity, it increases NAD+ levels and shifts metabolic pathways toward greater energy expenditure without changes in food intake.
Description
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism and fat storage regulation. By blocking NNMT activity, it increases NAD+ levels and shifts metabolic pathways toward greater energy expenditure without changes in food intake.Chemical Information
CAS Number
42464-96-0
Purity
99%+ HPLC Verified
Molecular Formula
C10H12N2
Molar Mass
160.2192 g/mol
Form Factor
Capsules
Synonyms
Research Applications
- Metabolic Research: 5-Amino-1MQ is studied as a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates cellular energy metabolism by methylating NAD+ precursors. Research examines how NNMT inhibition increases NAD+ levels, activates sirtuin longevity pathways, and shifts cellular metabolism from energy storage toward energy expenditure. Studies investigate the dose-response relationship and tissue-specific effects of NNMT inhibition.
- Obesity Science: 5-Amino-1MQ is studied for its ability to reprogram adipose tissue metabolism through NAD+ salvage pathway activation. Research demonstrates reduced adipocyte lipid accumulation, increased basal metabolic rate, and reversal of diet-induced obesity in animal models without changes in food intake. Studies examine the mechanisms linking NNMT inhibition to adipose tissue remodeling and whole-body energy balance.
- Epigenetics: 5-Amino-1MQ is studied for its effects on methylation pathway dynamics and metabolic gene regulation. By inhibiting NNMT, it alters the balance of S-adenosylmethionine (SAM) and nicotinamide metabolism, affecting DNA methylation patterns and histone modifications that regulate metabolic gene expression. Research examines these epigenetic consequences and their implications for metabolic disease and cellular aging.
- Pharmacology: 5-Amino-1MQ serves as a lead compound in NNMT inhibitor drug development. Research profiles its selectivity for NNMT over other methyltransferases, its oral bioavailability, tissue distribution, and metabolic stability. Studies compare its activity against other NNMT inhibitor scaffolds to establish structure-activity relationships and optimize pharmacological properties for potential therapeutic development.
Reconstitution Protocol
- 1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
- 2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
- 3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
- 4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
- 5 Label the vial with the reconstitution date and concentration.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Always note the reconstitution date on the vial label to track shelf life accurately.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for 5-Amino-1MQ (Capsules) — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
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5-Amino-1MQ inhibits NNMT to promote fat cell energy expenditure, pairing well with metabolic and weight-management peptides.
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