TB-500
Thymosin Beta-4 (43 Amino Acid)
CAS: 77591-33-4
Formula: C212H350N56O78S
M.W.: 4963.4421 g/mol
Purity: 99%+ HPLC Verified
Ref No.: TB-0010VI
For Research Use Only (RUO)
Not for human or veterinary use.
TB-500
Category
Tissue Repair / Regenerative Research
CAS Number
77591-33-4
Form Factor
Lyophilized Powder
In stock, ready to ship
Ships same day before 12pm PST
Products are shipped in lyophilized powder form.
TB-500 is a synthetic 43-amino-acid peptide representing the active region of Thymosin Beta-4. It regulates actin polymerization critical for cell migration and wound healing. Research demonstrates its ability to promote cell migration, reduce inflammation, inhibit apoptosis, and stimulate hair follicle growth.
Description
TB-500 is a synthetic 43-amino-acid peptide representing the active region of Thymosin Beta-4. It regulates actin polymerization critical for cell migration and wound healing. Research demonstrates its ability to promote cell migration, reduce inflammation, inhibit apoptosis, and stimulate hair follicle growth.Chemical Information
CAS Number
77591-33-4
Secondary CAS
885340-08-9
Purity
99%+ HPLC Verified
Molecular Formula
C212H350N56O78S
Molar Mass
4963.4421 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Regenerative Medicine: TB-500 is a cornerstone peptide in regenerative medicine research, studied across cardiac, dermal, hepatic, and musculoskeletal tissue repair models. Its primary mechanism — upregulation of actin, a key cell-building protein — promotes cell migration to injury sites, enabling tissue regeneration. Research demonstrates accelerated wound closure, reduced scar formation, and functional tissue restoration in multiple organ systems.
- Cell Biology: TB-500 serves as a critical research tool for understanding actin polymerization dynamics and their role in cell migration. Studies examine how Thymosin Beta-4 sequesters G-actin monomers, regulates cytoskeletal organization, and coordinates the cell motility essential for tissue repair. This fundamental cell biology research has implications for developmental biology, cancer metastasis understanding, and regenerative therapeutics.
- Dermatology: TB-500 is actively studied in dermatological research for its dual effects on wound healing and hair follicle regeneration. Studies show it promotes keratinocyte and endothelial cell migration, accelerates re-epithelialization of dermal wounds, and activates hair follicle stem cells from telogen to anagen phase. These properties make it valuable in alopecia, chronic wound, and skin aging research.
- Cardiology: TB-500 has demonstrated significant cardioprotective effects in ischemia-reperfusion injury models. Research shows it reduces cardiomyocyte apoptosis, promotes cardiac progenitor cell migration to damaged areas, and attenuates fibrotic remodeling following myocardial infarction. Its ability to preserve cardiac function after ischemic events positions it as a key compound in cardiovascular repair and regeneration studies.
- Immunology: As a derivative of Thymosin Beta-4, TB-500 is studied for its anti-inflammatory and immunomodulatory properties. Research demonstrates suppression of pro-inflammatory cytokines (IL-1β, TNF-α), reduction of neutrophil infiltration at injury sites, and modulation of macrophage polarization toward anti-inflammatory M2 phenotypes. These properties are relevant to autoimmune disease, transplant rejection, and chronic inflammation research.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for TB-500 — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
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Description
TB-500 is a synthetic 43-amino-acid peptide representing the active region of Thymosin Beta-4. It regulates actin polymerization critical for cell migration and wound healing. Research demonstrates its ability to promote cell migration, reduce inflammation, inhibit apoptosis, and stimulate hair follicle growth.Chemical Information
CAS Number
77591-33-4
Secondary CAS
885340-08-9
Purity
99%+ HPLC Verified
Molecular Formula
C212H350N56O78S
Molar Mass
4963.4421 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Regenerative Medicine: TB-500 is a cornerstone peptide in regenerative medicine research, studied across cardiac, dermal, hepatic, and musculoskeletal tissue repair models. Its primary mechanism — upregulation of actin, a key cell-building protein — promotes cell migration to injury sites, enabling tissue regeneration. Research demonstrates accelerated wound closure, reduced scar formation, and functional tissue restoration in multiple organ systems.
- Cell Biology: TB-500 serves as a critical research tool for understanding actin polymerization dynamics and their role in cell migration. Studies examine how Thymosin Beta-4 sequesters G-actin monomers, regulates cytoskeletal organization, and coordinates the cell motility essential for tissue repair. This fundamental cell biology research has implications for developmental biology, cancer metastasis understanding, and regenerative therapeutics.
- Dermatology: TB-500 is actively studied in dermatological research for its dual effects on wound healing and hair follicle regeneration. Studies show it promotes keratinocyte and endothelial cell migration, accelerates re-epithelialization of dermal wounds, and activates hair follicle stem cells from telogen to anagen phase. These properties make it valuable in alopecia, chronic wound, and skin aging research.
- Cardiology: TB-500 has demonstrated significant cardioprotective effects in ischemia-reperfusion injury models. Research shows it reduces cardiomyocyte apoptosis, promotes cardiac progenitor cell migration to damaged areas, and attenuates fibrotic remodeling following myocardial infarction. Its ability to preserve cardiac function after ischemic events positions it as a key compound in cardiovascular repair and regeneration studies.
- Immunology: As a derivative of Thymosin Beta-4, TB-500 is studied for its anti-inflammatory and immunomodulatory properties. Research demonstrates suppression of pro-inflammatory cytokines (IL-1β, TNF-α), reduction of neutrophil infiltration at injury sites, and modulation of macrophage polarization toward anti-inflammatory M2 phenotypes. These properties are relevant to autoimmune disease, transplant rejection, and chronic inflammation research.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for TB-500 — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
