AOD-9604

Modified GH Fragment (Anti-Obesity Drug)

CAS: 221231-10-3

Formula: C₇₈H₁₂₃N₂₃O₂₃S₂

M.W.: 1815.0738 g/mol

Purity: 99%+ HPLC Verified

Ref No.: AOD-0005VI

For Research Use Only (RUO)

Not for human or veterinary use.

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99%+ HPLC Verified Purity

AOD-9604

Name: AOD-9604
SKU: aod-9604
Availability: InStock

Category

GLP / Metabolic

CAS Number

221231-10-3

Form Factor

Lyophilized Powder

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5 mg

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AOD-9604 is a modified fragment of human growth hormone (amino acids 176-191) that retains lipolytic activity while having no effect on blood sugar, IGF-1 levels, or tissue growth. It stimulates lipolysis and inhibits lipogenesis in adipose tissue without growth hormone’s proliferative side effects.

CAS Number

221231-10-3

Purity

99%+ HPLC Verified

Molecular Formula

C₇₈H₁₂₃N₂₃O₂₃S₂

Molar Mass

1815.0738 g/mol

Form Factor

Lyophilized Powder

Synonyms

hGH Fragment 177-191 Tyr-hGH 177-191

Obesity Research: AOD-9604 is a modified fragment of human growth hormone (amino acids 176-191) studied specifically for lipolytic activity without growth hormone's proliferative or diabetogenic effects. Research examines its mechanism of fat cell triglyceride hydrolysis, inhibition of lipogenesis, and the signaling pathways through which it modulates adipose tissue metabolism independently of IGF-1 elevation.
Orthopedic Medicine: AOD-9604 is actively studied for cartilage regeneration and osteoarthritis treatment. Research demonstrates stimulation of proteoglycan and collagen synthesis in chondrocyte cultures, inhibition of cartilage-degrading enzymes (MMP-13), and functional improvement in animal osteoarthritis models. The Australian TGA has approved it for investigation as an anti-arthritic compound.
Metabolic Research: AOD-9604 is studied for its specific inhibition of lipogenesis in adipose tissue models. Research examines its effects on fatty acid synthase activity, acetyl-CoA carboxylase regulation, and the net flux of lipid metabolism in fat cells. Unlike full-length GH, it does not affect blood glucose or stimulate IGF-1, providing a clean metabolic research tool.
Safety Pharmacology: AOD-9604 serves as a model compound for GH fragment activity profiling. Research systematically characterizes which biological effects of growth hormone are retained and which are absent in the 176-191 fragment, informing the development of next-generation GH-derived peptides with targeted activity and minimal off-target effects.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.