NAD+ (buffered)

Nicotinamide Adenine Dinucleotide

CAS: 53-84-9

Formula: C₂₁H₂₈N₇O₁₄P₂

M.W.: 664.4242 g/mol

Purity: 99%+ HPLC Verified

Ref No.:NAD-0500VI

For Research Use Only (RUO)

Not for human or veterinary use.

COA Included With Every Order

Third-Party Lab Tested

Cold-Chain Packaging Included

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99%+ HPLC Verified Purity

NAD+ (buffered)

Name: NAD+ (buffered)
SKU: 810000000060
Availability: InStock

Category

GH / Neuro / Misc

CAS Number

53-84-9

Form Factor

Lyophilized Powder

Select mg:

500 mg

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Products are shipped in freeze dried powder form.

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme present in every cell, serving as an electron carrier and substrate for sirtuins, PARPs, and CD38. NAD+ levels decline ~50% between ages 40-60. Restoring levels activates sirtuin longevity pathways, enhances mitochondrial function, and improves DNA repair capacity.

CAS Number

53-84-9

Purity

99%+ HPLC Verified

Molecular Formula

C₂₁H₂₈N₇O₁₄P₂

Molar Mass

664.4242 g/mol

Form Factor

Lyophilized Powder

Synonyms

Nicotinamide Adenine Dinucleotide β-NAD+

Longevity Science: NAD+ is studied as a critical substrate for sirtuin-mediated lifespan research. NAD+ levels decline approximately 50% between ages 40 and 60, correlating with reduced sirtuin activity, impaired DNA repair, and accelerated cellular aging. Research examines whether exogenous NAD+ repletion can reactivate sirtuin longevity pathways, enhance PARP-mediated genome maintenance, and restore CD38-dependent calcium signaling in aged cells. The buffered formulation reduces injection-site irritation for chronic research protocols.
Neuroscience: NAD+ is studied for neuroprotection and cognitive decline prevention through multiple mechanisms. Research examines its role as a substrate for SIRT1-mediated neuroprotection, PARP-1-dependent DNA repair in neurons, and the maintenance of mitochondrial function in brain tissue. Studies investigate whether NAD+ repletion can protect against age-related neurodegeneration, improve cognitive function in aging models, and support the metabolic demands of active neural tissue.
Mitochondrial Medicine: NAD+ is an essential electron carrier in the mitochondrial electron transport chain, making it a critical research compound in mitochondrial medicine. Research examines the relationship between NAD+/NADH ratios and respiratory complex activity, the effects of NAD+ depletion on ATP production, and whether exogenous NAD+ supplementation can rescue mitochondrial dysfunction in aging, metabolic disease, and mitochondrial myopathy models.
DNA Repair: NAD+ serves as the essential substrate for poly(ADP-ribose) polymerases (PARPs) — enzymes that detect and repair DNA damage. Research examines how age-related NAD+ depletion compromises PARP activity and genomic stability, whether NAD+ supplementation enhances DNA repair capacity, and the relationship between NAD+ levels, PARP activity, and cancer susceptibility in aging and environmental exposure models.
Metabolic Research: NAD+ is studied for its central role in cellular energy metabolism and insulin sensitivity. Research examines its effects on glycolysis, the tricarboxylic acid cycle, and fatty acid oxidation through its function as a redox cofactor. Studies investigate whether NAD+ repletion improves metabolic flexibility, enhances insulin signaling, and reverses the metabolic inflexibility characteristic of type 2 diabetes and metabolic syndrome.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.

Quality Assurance Standards

Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.

Certificate of Analysis

Latest COA for NAD+ (buffered) — independently tested via HPLC and Mass Spectrometry.

COA-NAD-01-2025

Testing Methodology

Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.

• HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
• Mass Spectrometry — Validates molecular identity and correct sequence.
• Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
• Sterility — Microbial contamination testing per USP standards.