MOTS-c
Mitochondrial-Derived Peptide
CAS: 1627580-64-6
Formula: C101H152N28O22S2
M.W.: 2174.6231 g/mol
Purity: 99%+ HPLC Verified
Ref No.: MOT-0010VI
For Research Use Only (RUO)
Not for human or veterinary use.
MOTS-c
Category
GLP / Metabolic Research
CAS Number
1627580-64-6
Form Factor
Lyophilized Powder
In stock, ready to ship
Ships same day before 12pm PST
Products are shipped in lyophilized powder form.
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial genome that functions as a retrograde signaling molecule regulating metabolic homeostasis, insulin sensitivity, and stress responses through AMPK pathway activation. Designated in research literature as an “exercise mimetic,” endogenous levels are observed to decline with age in study models.
Description
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial genome that functions as a retrograde signaling molecule regulating metabolic homeostasis, insulin sensitivity, and stress responses through AMPK pathway activation. Designated in research literature as an "exercise mimetic," endogenous levels are observed to decline with age in study models.Chemical Information
CAS Number
1627580-64-6
Purity
99%+ HPLC Verified
Molecular Formula
C101H152N28O22S2
Molar Mass
2174.6231 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Metabolic Research: MOTS-c is studied as a mitochondrial-derived peptide that acts as a retrograde signaling molecule from mitochondria to the nucleus. Research examines how it activates AMPK to improve glucose uptake, fatty acid oxidation, and metabolic flexibility in preclinical models.
- Exercise Mimetic Research: MOTS-c is designated an exercise mimetic because it activates many of the same metabolic pathways engaged during physical exercise. Research examines whether MOTS-c administration can recapitulate exercise-associated metabolic pathway activation in preclinical study models.
- Aging Model Research: Endogenous MOTS-c levels are observed to decline with age in study models, correlating with reduced metabolic flexibility and increased insulin resistance. Research examines whether exogenous MOTS-c modulates these age-associated metabolic changes in aging model systems.
- Glycemic Research: MOTS-c is studied in insulin resistance and glucose dysregulation models for its insulin-sensitizing effects. Research demonstrates improved glucose tolerance, reduced hepatic gluconeogenesis, and enhanced skeletal muscle glucose uptake in preclinical models.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for MOTS-c — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
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Description
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial genome that functions as a retrograde signaling molecule regulating metabolic homeostasis, insulin sensitivity, and stress responses through AMPK pathway activation. Designated in research literature as an "exercise mimetic," endogenous levels are observed to decline with age in study models.Chemical Information
CAS Number
1627580-64-6
Purity
99%+ HPLC Verified
Molecular Formula
C101H152N28O22S2
Molar Mass
2174.6231 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Metabolic Research: MOTS-c is studied as a mitochondrial-derived peptide that acts as a retrograde signaling molecule from mitochondria to the nucleus. Research examines how it activates AMPK to improve glucose uptake, fatty acid oxidation, and metabolic flexibility in preclinical models.
- Exercise Mimetic Research: MOTS-c is designated an exercise mimetic because it activates many of the same metabolic pathways engaged during physical exercise. Research examines whether MOTS-c administration can recapitulate exercise-associated metabolic pathway activation in preclinical study models.
- Aging Model Research: Endogenous MOTS-c levels are observed to decline with age in study models, correlating with reduced metabolic flexibility and increased insulin resistance. Research examines whether exogenous MOTS-c modulates these age-associated metabolic changes in aging model systems.
- Glycemic Research: MOTS-c is studied in insulin resistance and glucose dysregulation models for its insulin-sensitizing effects. Research demonstrates improved glucose tolerance, reduced hepatic gluconeogenesis, and enhanced skeletal muscle glucose uptake in preclinical models.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for MOTS-c — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
