MOTS-c

Mitochondrial-Derived Peptide

CAS: 1627580-64-6

Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂

M.W.: 2174.6231 g/mol

Purity: 99%+ HPLC Verified

Ref No.: MOT-0010VI

For Research Use Only (RUO)

Not for human or veterinary use.

COA Included With Every Order

Third-Party Lab Tested

Cold-Chain Packaging Included

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99%+ HPLC Verified Purity

MOTS-c

Name: MOTS-c
SKU: mots-c
Availability: InStock

Category

GLP / Metabolic

CAS Number

1627580-64-6

Form Factor

Lyophilized Powder

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10 mg

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MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial genome that functions as a retrograde signaling molecule regulating metabolic homeostasis, insulin sensitivity, and stress responses through AMPK pathway activation. Often called an “exercise mimetic,” its levels naturally decline with age.

MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial genome that functions as a retrograde signaling molecule regulating metabolic homeostasis, insulin sensitivity, and stress responses through AMPK pathway activation. Often called an "exercise mimetic," its levels naturally decline with age.

CAS Number

1627580-64-6

Purity

99%+ HPLC Verified

Molecular Formula

C₁₀₁H₁₅₂N₂₈O₂₂S₂

Molar Mass

2174.6231 g/mol

Form Factor

Lyophilized Powder

Synonyms

Mitochondrial ORF-c MOTSc

Metabolic Research: MOTS-c is studied as a mitochondrial-derived peptide that acts as a retrograde signaling molecule from mitochondria to the nucleus. Research examines how it activates AMPK, the master cellular energy sensor, to improve glucose uptake, fatty acid oxidation, and metabolic flexibility. Studies investigate its role in maintaining metabolic homeostasis during nutritional stress and its therapeutic potential for metabolic syndrome.
Exercise Science: MOTS-c is designated an "exercise mimetic" because it activates many of the same metabolic pathways engaged during physical exercise. Research examines whether MOTS-c administration can recapitulate the metabolic benefits of exercise in sedentary models, including improved insulin sensitivity, enhanced mitochondrial biogenesis, and increased skeletal muscle oxidative capacity. Studies compare its effects to actual exercise and other exercise mimetic compounds.
Gerontology: MOTS-c levels naturally decline with age, correlating with reduced metabolic flexibility and increased insulin resistance. Gerontological research examines whether exogenous MOTS-c administration can reverse these age-related metabolic changes, restore youthful mitochondrial function, and improve overall metabolic health in aging models. Studies investigate the mechanisms linking mitochondrial peptide decline to the aging phenotype.
Diabetes Research: MOTS-c is actively studied in type 2 diabetes models for its insulin-sensitizing effects. Research demonstrates improved glucose tolerance, reduced hepatic gluconeogenesis, and enhanced skeletal muscle glucose uptake following MOTS-c administration. Studies examine whether these effects are mediated through AMPK-dependent or independent pathways and their durability during chronic treatment protocols.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.

Quality Assurance Standards

Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.

Certificate of Analysis

Latest COA for MOTS-c — independently tested via HPLC and Mass Spectrometry.

COA-MOTSC-09-2025

Testing Methodology

Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.

• HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
• Mass Spectrometry — Validates molecular identity and correct sequence.
• Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
• Sterility — Microbial contamination testing per USP standards.