5-Amino-1MQ

NNMT Inhibitor – Small Molecule Metabolic Modulator

CAS: 42464-96-0

Formula: C₁₀H₁₂N₂

M.W.: 160.2192 g/mol

Purity: 99%+ HPLC Verified

Ref No.: 5-A-0005VI

For Research Use Only (RUO)

Not for human or veterinary use.

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5-Amino-1MQ

Name: 5-Amino-1MQ
SKU: 5-amino-1mq-vial
Availability: InStock

Category

GLP / Metabolic Research

CAS Number

42464-96-0

Form Factor

Lyophilized Powder

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5 mg

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5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) in injectable lyophilized form. By blocking NNMT activity, it increases NAD+ levels and shifts metabolic pathways toward greater energy expenditure. The injectable format enables precise dosing for controlled metabolic research protocols.

CAS Number

42464-96-0

Purity

99%+ HPLC Verified

Molecular Formula

C₁₀H₁₂N₂

Molar Mass

160.2192 g/mol

Form Factor

Lyophilized Powder

Synonyms

5-Amino-1-Methylquinolinium NNMT Inhibitor

Metabolic Research: 5-Amino-1MQ is studied as a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates cellular energy metabolism by methylating NAD+ precursors. Research examines how NNMT inhibition increases NAD+ levels, activates sirtuin longevity pathways, and shifts cellular metabolism from energy storage toward energy expenditure. Studies investigate the dose-response relationship and tissue-specific effects of NNMT inhibition.
Obesity Science: 5-Amino-1MQ is studied for its ability to reprogram adipose tissue metabolism through NAD+ salvage pathway activation. Research demonstrates reduced adipocyte lipid accumulation, increased basal metabolic rate, and reversal of diet-induced obesity in animal models without changes in food intake. Studies examine the mechanisms linking NNMT inhibition to adipose tissue remodeling and whole-body energy balance.
Epigenetics: 5-Amino-1MQ is studied for its effects on methylation pathway dynamics and metabolic gene regulation. By inhibiting NNMT, it alters the balance of S-adenosylmethionine (SAM) and nicotinamide metabolism, affecting DNA methylation patterns and histone modifications that regulate metabolic gene expression. Research examines these epigenetic consequences and their implications for metabolic disease and cellular aging.
Pharmacology: 5-Amino-1MQ serves as a lead compound in NNMT inhibitor drug development. Research profiles its selectivity for NNMT over other methyltransferases, its oral bioavailability, tissue distribution, and metabolic stability. Studies compare its activity against other NNMT inhibitor scaffolds to establish structure-activity relationships and optimize pharmacological properties for potential therapeutic development.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.