GLP-3 (RT)
Triple Agonist
CAS: 2381089-83-2
Formula: C221H342N46O68
M.W.: 4731.3263 g/mol
Purity: 99%+ HPLC Verified
Ref No.:RET-0005VI
Ref No.:RET-0010VI
Ref No.:RET-0015VI
For Research Use Only (RUO)
Not for human or veterinary use.
GLP-3 (RT)
Category
GLP / Metabolic Research
CAS Number
2381089-83-2
Form Factor
Lyophilized Powder
In stock, ready to ship
Ships same day before 12pm PST
Products are shipped in sealed sterile vials.
GLP-3 (RT) is a triple-agonist peptide simultaneously activating GLP-1, GIP, and glucagon receptors. Early clinical data shows unprecedented weight reduction exceeding 24% at higher doses. The glucagon component adds thermogenesis and liver fat clearance absent from dual-agonists.
Description
GLP-3 (RT) is a triple-agonist peptide simultaneously activating GLP-1, GIP, and glucagon receptors. Early clinical data shows unprecedented weight reduction exceeding 24% at higher doses. The glucagon component adds thermogenesis and liver fat clearance absent from dual-agonists.Chemical Information
CAS Number
2381089-83-2
Purity
99%+ HPLC Verified
Molecular Formula
C221H342N46O68
Molar Mass
4731.3263 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Metabolic Research: GLP-3 (RT) is the most advanced triple-agonist peptide studied in metabolic research, simultaneously activating GLP-1, GIP, and glucagon receptors. Early-phase clinical data demonstrate unprecedented weight reduction exceeding 24% at higher doses, surpassing existing dual-agonists. Research focuses on understanding how the three-receptor mechanism produces these dramatic results and optimizing dose-response relationships.
- Hepatology: The glucagon receptor component of GLP-3 (RT) provides unique hepatic research applications. Glucagon receptor activation enhances hepatic lipid oxidation and promotes liver fat clearance — effects absent from GLP-1-only and dual-agonist peptides. Research investigates its potential in NASH treatment, examining liver fat reduction, fibrosis scores, and hepatic inflammatory markers in preclinical and clinical study settings.
- Endocrinology: GLP-3 (RT) is studied for its complex multi-receptor interactions across the endocrine system. Research examines how simultaneous GLP-1, GIP, and glucagon receptor activation affects insulin secretion dynamics, glucose counter-regulation, and metabolic hormone cross-talk. Understanding these interactions is critical for optimizing therapeutic windows and predicting long-term metabolic outcomes.
- Thermogenesis: The glucagon receptor agonism of GLP-3 (RT) provides a unique thermogenic component not found in other incretin-class peptides. Research examines glucagon-mediated increases in resting energy expenditure, brown adipose tissue activation, and substrate oxidation rates. These studies aim to determine what proportion of the peptide's weight loss effect is attributable to reduced intake versus increased expenditure.
Reconstitution Protocol
- 1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
- 2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
- 3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
- 4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
- 5 Label the vial with the reconstitution date and concentration.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Always note the reconstitution date on the vial label to track shelf life accurately.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for GLP-3 (RT) — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
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