Tesamorelin
GHRH Analog
CAS: 218949-48-5
Formula: C221H366N72O67S
M.W.: 5135.85 g/mol
Purity: 99%+ HPLC Verified
Ref No.: TES-0005VI
Ref No.: TES-0010VI
For Research Use Only (RUO)
Not for human or veterinary use.
Tesamorelin
Category
GH / Neuro / Misc
CAS Number
218949-48-5
Form Factor
Lyophilized Powder
In stock, ready to ship
Ships same day before 12pm PST
Products are shipped in freeze dried powder form.
Tesamorelin is a 44-amino-acid GHRH analog and the only one with FDA approval, indicated for visceral fat reduction in HIV lipodystrophy. Research also reveals cognitive benefits — improved verbal memory, executive function, and hippocampal volume preservation in older adults with mild cognitive impairment.
Description
Tesamorelin is a 44-amino-acid GHRH analog and the only one with FDA approval, indicated for visceral fat reduction in HIV lipodystrophy. Research also reveals cognitive benefits — improved verbal memory, executive function, and hippocampal volume preservation in older adults with mild cognitive impairment.Chemical Information
CAS Number
218949-48-5
Secondary CAS
901758-09-6
Purity
99%+ HPLC Verified
Molecular Formula
C221H366N72O67S
Molar Mass
5135.85 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- HIV Medicine: Tesamorelin is the only GHRH analog with FDA approval, indicated for reducing excess abdominal fat in HIV-infected patients with lipodystrophy. Research examines the mechanisms of visceral fat reduction, improvements in trunk/limb fat ratio, and the metabolic consequences including lipid profile normalization and insulin sensitivity improvement in this specific patient population.
- Neuroscience: Tesamorelin is actively studied for cognitive function enhancement and hippocampal volume preservation in older adults. Research in mild cognitive impairment populations demonstrates improved verbal memory, executive function, and brain-derived neurotrophic factor levels. Neuroimaging studies show preservation of hippocampal volume and cortical thickness, suggesting neuroprotective effects mediated through the GH-IGF-1 axis.
- Endocrinology: Tesamorelin's FDA-approved status provides robust clinical frameworks for studying GHRH analog pharmacology. Research examines dose-response relationships, long-term pituitary responsiveness, IGF-1 elevation kinetics, and the metabolic consequences of chronic GHRH analog stimulation versus exogenous GH replacement in controlled clinical settings.
- Metabolic Research: Tesamorelin is studied for its specific effects on visceral adiposity and associated metabolic dysfunction. Research examines reductions in visceral fat volume (measured by CT scan), improvements in hepatic fat content, triglyceride normalization, and the relationship between visceral fat reduction and cardiometabolic risk factor improvement.
Reconstitution Protocol
- 1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
- 2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
- 3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
- 4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
- 5 Label the vial with the reconstitution date and concentration.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Always note the reconstitution date on the vial label to track shelf life accurately.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for Tesamorelin — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
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Research Database
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Tesamorelin (GHRH analog) stimulates GH release and is commonly paired with GH secretagogues and metabolic peptides.
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