Semax

ACTH Analog – Nootropic

CAS: 80714-61-0

Formula: C₃₇H₅₁N₉O₁₀S

M.W.: 813.9255 g/mol

Purity: 99%+ HPLC Verified

Ref No.: SEM-0005VI

For Research Use Only (RUO)

Not for human or veterinary use.

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99%+ HPLC Verified Purity

Semax

Name: Semax
SKU: semax
Availability: InStock

Category

GH / Neuro / Misc

CAS Number

80714-61-0

Form Factor

Lyophilized Powder

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5 mg

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Semax is a synthetic ACTH(4-10) analog developed for stroke and cognitive disorders. It upregulates BDNF and NGF, modulates serotonergic and dopaminergic neurotransmission, and has received regulatory approval in Russia for stroke treatment. Research shows improvements in memory, attention, and neuroprotection.

CAS Number

80714-61-0

Secondary CAS

183557-49-9

Purity

99%+ HPLC Verified

Molecular Formula

C₃₇H₅₁N₉O₁₀S

Molar Mass

813.9255 g/mol

Form Factor

Lyophilized Powder

Synonyms

Semax Acetate ACTH (4-10) Analog

Neurology: Semax is studied in stroke recovery and ischemic neuroprotection research, with regulatory approval in Russia for acute stroke treatment. Research examines its effects on infarct volume reduction, neurological deficit scores, and functional recovery following ischemic events. Studies investigate the mechanisms of neuroprotection, including BDNF/NGF upregulation, anti-apoptotic signaling, and cerebrovascular blood flow modulation.
Cognitive Science: Semax is extensively studied for its nootropic effects on memory formation, attention, and executive function. Research demonstrates enhanced performance on spatial memory tasks, improved working memory capacity, and accelerated cognitive processing speed. Studies examine whether these effects are mediated through neurotrophic factor upregulation, cholinergic system modulation, or dopaminergic pathway enhancement.
Neuropharmacology: Semax is a model compound for studying BDNF and NGF upregulation mechanisms. Research examines the time course of neurotrophic factor elevation, the receptor systems involved, and the downstream effects on synaptic plasticity, long-term potentiation, and dendritic morphology. These fundamental studies inform therapeutic development for neurodegenerative and cognitive disorders.
Clinical Neuroscience: Semax serves as one of the few regulatory-approved nootropic peptides, providing validated clinical study models for cognitive enhancement research. Russian clinical data spanning decades provides a foundation for studying long-term nootropic efficacy, safety, and the translation of preclinical neurotrophic effects into measurable cognitive outcomes in human subjects.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.