Sermorelin
GHRH Analog
CAS: 86168-78-7
Formula: C149H246N44O42S
M.W.: 3357.9319 g/mol
Purity: 99%+ HPLC Verified
Ref No.: SER-0005VI
For Research Use Only (RUO)
Not for human or veterinary use.
Sermorelin
Category
GH / Neuro / Misc Research
CAS Number
86168-78-7
Form Factor
Lyophilized Powder
In stock, ready to ship
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Products are shipped in lyophilized powder form.
Sermorelin (GRF 1-29 NH2) is a synthetic analog of the first 29 amino acids of GHRH. It stimulates endogenous GH production while preserving natural feedback mechanisms and pulsatile secretion, providing a validated research compound for GHRH-axis biology with extensive prior clinical development data.
Description
Sermorelin (GRF 1-29 NH2) is a synthetic analog of the first 29 amino acids of GHRH. It stimulates endogenous GH production while preserving natural feedback mechanisms and pulsatile secretion, providing a validated research compound for GHRH-axis biology with extensive prior clinical development data.
Chemical Information
CAS Number
86168-78-7
Secondary CAS
114466-38-5
Purity
99%+ HPLC Verified
Molecular Formula
C149H246N44O42S
Molar Mass
3357.9319 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Endocrinology: Sermorelin (GRF 1-29 NH2) is studied as a physiological GH stimulation model that activates endogenous pituitary GH production rather than providing exogenous GH. Research examines how it preserves natural pulsatile secretion patterns, maintains hypothalamic-pituitary feedback, and avoids the supraphysiological GH levels associated with exogenous GH administration. Its prior clinical development data provides validated study frameworks.
- Gerontology: Sermorelin is studied in aging research for its ability to reverse somatopause-associated GH decline in elderly subjects. Research examines age-related changes in pituitary responsiveness to GHRH stimulation, the reversibility of GH decline through chronic GHRH analog administration, and the metabolic, tissue composition, and functional outcomes of restored GH pulsatility in aging research models.
- Pediatric Endocrinology: Sermorelin previously had prior clinical development data for pediatric growth hormone deficiency diagnosis and study intervention, providing extensive study safety and efficacy data. Research continues to examine its effects on growth velocity, longitudinal skeletal development outcomes, and pituitary reserve testing applications in juvenile subjects with suspected GH deficiency or constitutional growth delay.
- Sleep Medicine: Sermorelin is studied for its effects on nocturnal GH secretion and sleep quality. Research demonstrates enhanced GH pulse amplitude during slow-wave sleep, improved sleep quality metrics, and increased proportion of deep sleep stages. Studies examine the bidirectional relationship between GH secretion and sleep architecture modulation.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
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Popular Product
Description
Sermorelin (GRF 1-29 NH2) is a synthetic analog of the first 29 amino acids of GHRH. It stimulates endogenous GH production while preserving natural feedback mechanisms and pulsatile secretion, providing a validated research compound for GHRH-axis biology with extensive prior clinical development data.
Chemical Information
CAS Number
86168-78-7
Secondary CAS
114466-38-5
Purity
99%+ HPLC Verified
Molecular Formula
C149H246N44O42S
Molar Mass
3357.9319 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Endocrinology: Sermorelin (GRF 1-29 NH2) is studied as a physiological GH stimulation model that activates endogenous pituitary GH production rather than providing exogenous GH. Research examines how it preserves natural pulsatile secretion patterns, maintains hypothalamic-pituitary feedback, and avoids the supraphysiological GH levels associated with exogenous GH administration. Its prior clinical development data provides validated study frameworks.
- Gerontology: Sermorelin is studied in aging research for its ability to reverse somatopause-associated GH decline in elderly subjects. Research examines age-related changes in pituitary responsiveness to GHRH stimulation, the reversibility of GH decline through chronic GHRH analog administration, and the metabolic, tissue composition, and functional outcomes of restored GH pulsatility in aging research models.
- Pediatric Endocrinology: Sermorelin previously had prior clinical development data for pediatric growth hormone deficiency diagnosis and study intervention, providing extensive study safety and efficacy data. Research continues to examine its effects on growth velocity, longitudinal skeletal development outcomes, and pituitary reserve testing applications in juvenile subjects with suspected GH deficiency or constitutional growth delay.
- Sleep Medicine: Sermorelin is studied for its effects on nocturnal GH secretion and sleep quality. Research demonstrates enhanced GH pulse amplitude during slow-wave sleep, improved sleep quality metrics, and increased proportion of deep sleep stages. Studies examine the bidirectional relationship between GH secretion and sleep architecture modulation.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
