NAD+ (Spray)

Nicotinamide Adenine Dinucleotide (Nasal)

CAS: 53-84-9

Formula: C₂₁H₂₈N₇O₁₄P₂

M.W.: 664.4242 g/mol

Purity: 99%+ HPLC Verified

Ref No.: NAD-1500SP

For Research Use Only (RUO)

Not for human or veterinary use.

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99%+ HPLC Verified Purity

NAD+ (Spray)

Name: NAD+ (Spray)
SKU: nad-spray
Availability: InStock

Category

GH / Neuro / Misc

CAS Number

53-84-9

Form Factor

Nasal Spray

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1500 mg (30 ml)

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NAD+ Nasal Spray delivers Nicotinamide Adenine Dinucleotide intranasally for rapid cellular uptake and enhanced bioavailability compared to oral supplementation. It supports sirtuin activation, DNA repair, mitochondrial function, and neuroprotection against age-related cognitive decline via the nose-to-brain transport pathway.

CAS Number

53-84-9

Purity

99%+ HPLC Verified

Molecular Formula

C₂₁H₂₈N₇O₁₄P₂

Molar Mass

664.4242 g/mol

Form Factor

Nasal Spray

Synonyms

Nicotinamide Adenine Dinucleotide (Nasal)

Longevity Science: NAD+ nasal spray is studied for intranasal delivery of this critical coenzyme for sirtuin activation and anti-aging research. The nasal route offers enhanced bioavailability compared to oral supplementation by bypassing GI degradation and hepatic first-pass metabolism. Research examines the kinetics of nasal NAD+ absorption, systemic distribution, and the correlation between plasma NAD+ elevation and sirtuin-dependent gene expression changes.
Neuroscience: NAD+ spray is studied for nose-to-brain coenzyme delivery and neuroprotective applications. Research examines whether intranasal NAD+ reaches CNS targets in sufficient concentrations to support neuronal NAD+-dependent enzymes (sirtuins, PARPs, CD38), enhance mitochondrial function in brain tissue, and protect against age-related cognitive decline through direct CNS NAD+ repletion.
Pharmaceutical Sciences: NAD+ nasal spray is studied for coenzyme bioavailability optimization via intranasal delivery. Research examines spray formulation parameters (pH, tonicity, viscosity), NAD+ stability in aqueous nasal formulations, the effect of mucosal absorption enhancers, and comparative bioavailability against oral, sublingual, and intravenous NAD+ delivery routes.
Gerontology: NAD+ spray is studied for non-invasive NAD+ repletion in aging intervention research. Research examines whether intranasal delivery can achieve therapeutically relevant NAD+ elevation in elderly subjects, restore age-related NAD+ decline, and produce measurable improvements in mitochondrial function, DNA repair capacity, and sirtuin-mediated longevity pathway activation.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.