SS-31

Mitochondria-Targeted Tetrapeptide (Elamipretide)

CAS: 736992-21-5

Formula: C₃₂H₄₉N₉O₅

M.W.: 611.78 g/mol

Purity: 99%+ HPLC Verified

Ref No.: SS-0010VI

For Research Use Only (RUO)

Not for human or veterinary use.

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99%+ HPLC Verified Purity

SS-31

Name: SS-31
SKU: ss-31
Availability: InStock

Category

GH / Neuro / Misc

CAS Number

736992-21-5

Form Factor

Lyophilized Powder

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SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that concentrates in the inner mitochondrial membrane, stabilizing cardiolipin and optimizing electron transport ch

CAS Number

736992-21-5

Purity

99%+ HPLC Verified

Molecular Formula

C₃₂H₄₉N₉O₅

Molar Mass

611.78 g/mol

Form Factor

Lyophilized Powder

Synonyms

Elamipretide Bendavia MTP-131

Mitochondrial Medicine: SS-31 (Elamipretide) is a cell-penetrating peptide that selectively targets the inner mitochondrial membrane, where it binds to cardiolipin and stabilizes the electron transport chain. Research examines its effects on mitochondrial cristae structure, respiratory complex activity, and ATP production efficiency. Its specificity for dysfunctional mitochondria makes it a precision tool for mitochondrial disease and age-related mitochondrial decline research.
Cardiology: SS-31 is studied for mitochondrial protection in heart failure, ischemia-reperfusion injury, and cardiomyopathy models. Research demonstrates preserved cardiac contractile function, reduced infarct size, and improved mitochondrial membrane potential in ischemic myocardium. Clinical trials (as Elamipretide) have examined its effects in Barth syndrome cardiomyopathy and heart failure with preserved ejection fraction.
Nephrology: SS-31 is actively studied for renal mitochondrial protection in acute kidney injury and chronic kidney disease models. Research demonstrates preservation of renal tubular mitochondrial structure, reduced oxidative damage, and improved glomerular filtration following ischemic and toxic renal insults. Studies examine its potential for preventing contrast-induced nephropathy and protecting donor kidneys during transplantation.
Gerontology: SS-31 is studied for its ability to reverse age-related mitochondrial dysfunction. Research demonstrates improved mitochondrial energy production, reduced oxidative stress, and restored mitochondrial dynamics (fusion/fission balance) in aged tissue. Studies examine whether mitochondrial rejuvenation via SS-31 can reverse functional decline in skeletal muscle, cardiac tissue, and neural tissue in aging models.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.