Melanotan-2

Melanocortin Receptor Agonist (MT-II)

CAS: 121062-08-6

Formula: C₅₀H₆₉N₁₅O₉

M.W.: 1024.1785 g/mol

Purity: 99%+ HPLC Verified

Ref No.: ML2-0010VI

For Research Use Only (RUO)

Not for human or veterinary use.

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99%+ HPLC Verified Purity

Melanotan-2

Name: Melanotan-2
SKU: melanotan-2
Availability: InStock

Category

GH / Neuro / Misc

CAS Number

121062-08-6

Form Factor

Lyophilized Powder

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10 mg

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Melanotan II is a cyclic heptapeptide α-MSH analog that non-selectively activates multiple melanocortin receptors (MC1R-MC5R), producing diverse effects including skin pigmentation, appetite modulation, and sexual arousal signaling. Its MC4R agonism led to the development of FDA-approved PT-141 (Bremelanotide).

CAS Number

121062-08-6

Secondary CAS

192568-05-7

Purity

99%+ HPLC Verified

Molecular Formula

C₅₀H₆₉N₁₅O₉

Molar Mass

1024.1785 g/mol

Form Factor

Lyophilized Powder

Synonyms

Melanotan II MT-II

Dermatology: Melanotan-2 is studied for melanocortin-mediated skin pigmentation through non-selective activation of MC1R-MC5R. Research examines the kinetics of tanning response induction, the uniformity of melanin distribution, and the histological changes in melanocyte density and activity. Studies also monitor existing nevi for morphological changes, contributing to melanocyte biology and skin cancer risk assessment research.
Sexual Medicine: Melanotan-2's non-selective MC4R agonism produces sexual arousal effects that led to the development of PT-141 (Bremelanotide). Research continues to examine the melanocortin basis of sexual function, comparing MT-II's broader receptor activity profile against PT-141's more selective approach to understand the optimal receptor selectivity for sexual dysfunction therapy development.
Metabolic Research: Melanotan-2 is studied for appetite suppression and lipolytic effects mediated through central melanocortin signaling. Research examines MC4R-dependent anorexic effects, changes in food preference and caloric intake, and the direct lipolytic activity observed in adipose tissue models. Studies investigate whether these metabolic effects can be separated from pigmentation and sexual function effects through receptor-selective analog design.
Photobiology: Melanotan-2 is studied for its ability to induce protective tanning responses without UV exposure. Research examines the degree of photoprotection conferred by MT-II-induced melanin, the comparative UV damage between MT-II-tanned and UV-tanned skin, and the cellular mechanisms underlying pharmacological melanogenesis versus UV-induced melanogenesis.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.