VIP

Vasoactive Intestinal Peptide

CAS: 37221-79-7

Formula: C₁₄₇H₂₃₇N₄₃O₄₃S

M.W.: 3326.7906 g/mol

Purity: 99%+ HPLC Verified

Ref No.: VIP-0005VI

For Research Use Only (RUO)

Not for human or veterinary use.

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99%+ HPLC Verified Purity

VIP

Name: VIP
SKU: vip
Availability: InStock

Category

GH / Neuro / Misc

CAS Number

37221-79-7

Form Factor

Lyophilized Powder

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5 mg

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Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide functioning as a potent vasodilator, bronchodilator, immunomodulator, and neuroprotective agent through VPAC1/VPAC2 receptor activation. It shows promise in pulmonary hypertension, COPD, and neuroprotection while regulating circadian rhythms.

CAS Number

37221-79-7

Purity

99%+ HPLC Verified

Molecular Formula

C₁₄₇H₂₃₇N₄₃O₄₃S

Molar Mass

3326.7906 g/mol

Form Factor

Lyophilized Powder

Synonyms

Vasoactive Intestinal Peptide Aviptadil

Pulmonology: Vasoactive Intestinal Peptide (VIP) is studied as a potent bronchodilator and pulmonary vasodilator in respiratory medicine research. Studies examine its effects on pulmonary arterial hypertension, COPD-associated bronchospasm, and surfactant production in alveolar type II cells. Research investigates inhaled VIP formulations as alternatives to conventional bronchodilators with the additional benefit of anti-inflammatory activity.
Neuroscience: VIP is studied as a multifunctional neuropeptide with roles in neuroprotection, neuronal survival, and synaptic transmission. Research examines its effects on astrocyte activation, microglial polarization, and neuroinflammation resolution. Studies investigate VIP's neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and traumatic brain injury models through VPAC1/VPAC2 receptor signaling.
Immunology: VIP is studied for its immunomodulatory effects on T-cell regulation and autoimmune disease. Research demonstrates induction of regulatory T-cells, suppression of Th1/Th17 inflammatory responses, and protection against autoimmune tissue damage. Studies examine its therapeutic potential in rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and inflammatory bowel disease models.
Chronobiology: VIP is studied for its role in the suprachiasmatic nucleus (SCN), the brain's master circadian clock. Research examines how VIP neurons synchronize individual clock cells within the SCN, coordinate systemic circadian rhythms, and regulate the timing of hormonal secretion, sleep-wake cycles, and feeding behavior. Studies investigate VIP's potential for treating circadian rhythm disorders.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.