LL-37
Human Cathelicidin Antimicrobial Peptide
CAS: 154947-66-7
Formula: C205H340N60O53
M.W.: 4493.3328 g/mol
Purity: 99%+ HPLC Verified
Ref No.: LL-0005VI
For Research Use Only (RUO)
Not for human or veterinary use.
LL-37
Category
GH / Neuro / Misc Research
CAS Number
154947-66-7
Form Factor
Lyophilized Powder
In stock, ready to ship
Ships same day before 12pm PST
Products are shipped in lyophilized powder form.
LL-37 is the only cathelicidin-derived antimicrobial peptide found in humans, exhibiting broad-spectrum activity against bacteria, fungi, and viruses through membrane disruption. It also promotes chem
Description
LL-37 is the only cathelicidin-derived antimicrobial peptide found in humans, exhibiting broad-spectrum activity against bacteria, fungi, and viruses through membrane disruption. It also promotes chemChemical Information
CAS Number
154947-66-7
Purity
99%+ HPLC Verified
Molecular Formula
C205H340N60O53
Molar Mass
4493.3328 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Infectious Disease: LL-37 is the only human cathelicidin-derived antimicrobial peptide, studied for its broad-spectrum activity against bacteria, fungi, enveloped viruses, and parasites. Research examines its mechanism of membrane disruption, the development of antimicrobial resistance, and its efficacy against multi-drug resistant organisms including MRSA, VRE, and carbapenem-resistant Enterobacteriaceae.
- Biofilm Science: LL-37 is studied for its ability to disrupt established bacterial biofilms and prevent new biofilm formation. Research examines the concentrations required for biofilm penetration, the mechanisms of biofilm matrix disruption, and the synergistic effects of LL-37 with conventional antibiotics against biofilm-associated infections relevant to chronic wounds, device-related infections, and cystic fibrosis lung disease.
- Immunology: Beyond direct antimicrobial activity, LL-37 is studied as an innate immune modulator that bridges innate and adaptive immunity. Research examines its chemotactic activity for neutrophils and monocytes, modulation of dendritic cell differentiation, cytokine/chemokine production regulation, and enhancement of pathogen clearance through opsonization and complement activation.
- Wound Healing: LL-37 is studied in wound healing research for its dual antimicrobial and regenerative properties. Research demonstrates promotion of keratinocyte migration, stimulation of angiogenesis, and direct induction of wound closure alongside antimicrobial barrier function. Studies examine its potential in chronic wound management where infection and impaired healing coexist.
Laboratory Preparation Protocol
- 1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
- 2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
- 3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
- 4 Gently swirl (do not shake) the vial until the powder is fully dissolved and the solution appears clear, as shown in the vial image.
- 5 Label the vial with the reconstitution date and concentration.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Always note the reconstitution date on the vial label to track shelf life accurately.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
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Description
LL-37 is the only cathelicidin-derived antimicrobial peptide found in humans, exhibiting broad-spectrum activity against bacteria, fungi, and viruses through membrane disruption. It also promotes chemChemical Information
CAS Number
154947-66-7
Purity
99%+ HPLC Verified
Molecular Formula
C205H340N60O53
Molar Mass
4493.3328 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Infectious Disease: LL-37 is the only human cathelicidin-derived antimicrobial peptide, studied for its broad-spectrum activity against bacteria, fungi, enveloped viruses, and parasites. Research examines its mechanism of membrane disruption, the development of antimicrobial resistance, and its efficacy against multi-drug resistant organisms including MRSA, VRE, and carbapenem-resistant Enterobacteriaceae.
- Biofilm Science: LL-37 is studied for its ability to disrupt established bacterial biofilms and prevent new biofilm formation. Research examines the concentrations required for biofilm penetration, the mechanisms of biofilm matrix disruption, and the synergistic effects of LL-37 with conventional antibiotics against biofilm-associated infections relevant to chronic wounds, device-related infections, and cystic fibrosis lung disease.
- Immunology: Beyond direct antimicrobial activity, LL-37 is studied as an innate immune modulator that bridges innate and adaptive immunity. Research examines its chemotactic activity for neutrophils and monocytes, modulation of dendritic cell differentiation, cytokine/chemokine production regulation, and enhancement of pathogen clearance through opsonization and complement activation.
- Wound Healing: LL-37 is studied in wound healing research for its dual antimicrobial and regenerative properties. Research demonstrates promotion of keratinocyte migration, stimulation of angiogenesis, and direct induction of wound closure alongside antimicrobial barrier function. Studies examine its potential in chronic wound management where infection and impaired healing coexist.
Laboratory Preparation Protocol
- 1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
- 2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
- 3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
- 4 Gently swirl (do not shake) the vial until the powder is fully dissolved and the solution appears clear, as shown in the vial image.
- 5 Label the vial with the reconstitution date and concentration.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Always note the reconstitution date on the vial label to track shelf life accurately.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
