LL-37
Human Cathelicidin Antimicrobial Peptide
CAS: 154947-66-7
Formula: C205H340N60O53
M.W.: 4493.3328 g/mol
Purity: 99%+ HPLC Verified
Ref No.: LL-0005VI
For Research Use Only (RUO)
Not for human or veterinary use.
LL-37
Category
GH / Neuro / Misc Research
CAS Number
154947-66-7
Form Factor
Lyophilized Powder
In stock, ready to ship
Ships same day before 12pm PST
Products are shipped in lyophilized powder form.
LL-37 is the only cathelicidin-derived antimicrobial peptide found in humans, exhibiting broad-spectrum activity against bacteria, fungi, and viruses through membrane disruption. It also promotes chemotaxis, modulates cytokine production, stimulates angiogenesis, and disrupts bacterial biofilms. For laboratory research use only.
Description
LL-37 is the only cathelicidin-derived antimicrobial peptide found in humans, exhibiting broad-spectrum activity against bacteria, fungi, and viruses through membrane disruption. It also promotes chemotaxis, modulates cytokine production, stimulates angiogenesis, and disrupts bacterial biofilms. For laboratory research use only.Chemical Information
CAS Number
154947-66-7
Purity
99%+ HPLC Verified
Molecular Formula
C205H340N60O53
Molar Mass
4493.3328 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Infectious-Disease Research: LL-37 is investigated as a human cathelicidin-derived antimicrobial peptide with activity across bacterial, fungal, enveloped-viral, and parasitic models. Research examines membrane-disruption mechanisms, pathogen selectivity, concentration-response relationships, and activity against multidrug-resistant organisms.
- Biofilm Research: LL-37 is studied for its interactions with established microbial biofilms. Research parameters include biofilm penetration, matrix disruption, microbial viability, concentration thresholds, and combined activity with conventional antimicrobial compounds.
- Immunology Research: LL-37 is evaluated as a modulator of innate immune signaling. Investigations examine neutrophil and monocyte chemotaxis, dendritic-cell differentiation, cytokine responses, pattern-recognition pathways, and interactions between antimicrobial and immune-regulatory mechanisms.
- Tissue-Regeneration Research: LL-37 is studied for its combined antimicrobial and tissue-remodeling activity. Research endpoints include keratinocyte migration, angiogenic signaling, re-epithelialization, microbial burden, inflammatory responses, and tissue-closure kinetics.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for LL-37 — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
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Description
LL-37 is the only cathelicidin-derived antimicrobial peptide found in humans, exhibiting broad-spectrum activity against bacteria, fungi, and viruses through membrane disruption. It also promotes chemotaxis, modulates cytokine production, stimulates angiogenesis, and disrupts bacterial biofilms. For laboratory research use only.Chemical Information
CAS Number
154947-66-7
Purity
99%+ HPLC Verified
Molecular Formula
C205H340N60O53
Molar Mass
4493.3328 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Infectious-Disease Research: LL-37 is investigated as a human cathelicidin-derived antimicrobial peptide with activity across bacterial, fungal, enveloped-viral, and parasitic models. Research examines membrane-disruption mechanisms, pathogen selectivity, concentration-response relationships, and activity against multidrug-resistant organisms.
- Biofilm Research: LL-37 is studied for its interactions with established microbial biofilms. Research parameters include biofilm penetration, matrix disruption, microbial viability, concentration thresholds, and combined activity with conventional antimicrobial compounds.
- Immunology Research: LL-37 is evaluated as a modulator of innate immune signaling. Investigations examine neutrophil and monocyte chemotaxis, dendritic-cell differentiation, cytokine responses, pattern-recognition pathways, and interactions between antimicrobial and immune-regulatory mechanisms.
- Tissue-Regeneration Research: LL-37 is studied for its combined antimicrobial and tissue-remodeling activity. Research endpoints include keratinocyte migration, angiogenic signaling, re-epithelialization, microbial burden, inflammatory responses, and tissue-closure kinetics.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for LL-37 — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
