TB-500

Thymosin Beta-4 (43 Amino Acid)

CAS: 77591-33-4

Formula: C₂₁₂H₃₅₀N₅₆O₇₈S

M.W.: 4963.4421 g/mol

Purity: 99%+ HPLC Verified

Ref No.: TB-0010VI

For Research Use Only (RUO)

Not for human or veterinary use.

COA Included With Every Order

Third-Party Lab Tested

Cold-Chain Packaging Included

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99%+ HPLC Verified Purity

TB-500 (Capsules)

Name: TB-500 (Capsules)
SKU: tb-500-capsule
Availability: InStock

Category

Healing / Growth / Cosmetic

CAS Number

77591-33-4

Form Factor

Capsules

Select mg:

500 mcg (60 ct)

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Products are shipped in freeze dried powder form.

TB-500 (Thymosin Beta-4) in oral capsule form delivers this 43-amino-acid tissue repair peptide through the digestive tract. TB-500 regulates actin polymerization critical for cell migration and wound healing, and oral delivery provides a convenient non-invasive format for systemic tissue repair research.

CAS Number

77591-33-4

Secondary CAS

885340-08-9

Purity

99%+ HPLC Verified

Molecular Formula

C₂₁₂H₃₅₀N₅₆O₇₈S

Molar Mass

4963.4421 g/mol

Form Factor

Lyophilized Powder

Synonyms

Thymosin β-4 Fragment TB4

Regenerative Medicine: TB-500 is a cornerstone peptide in regenerative medicine research, studied across cardiac, dermal, hepatic, and musculoskeletal tissue repair models. Its primary mechanism — upregulation of actin, a key cell-building protein — promotes cell migration to injury sites, enabling tissue regeneration. Research demonstrates accelerated wound closure, reduced scar formation, and functional tissue restoration in multiple organ systems.
Cell Biology: TB-500 serves as a critical research tool for understanding actin polymerization dynamics and their role in cell migration. Studies examine how Thymosin Beta-4 sequesters G-actin monomers, regulates cytoskeletal organization, and coordinates the cell motility essential for tissue repair. This fundamental cell biology research has implications for developmental biology, cancer metastasis understanding, and regenerative therapeutics.
Dermatology: TB-500 is actively studied in dermatological research for its dual effects on wound healing and hair follicle regeneration. Studies show it promotes keratinocyte and endothelial cell migration, accelerates re-epithelialization of dermal wounds, and activates hair follicle stem cells from telogen to anagen phase. These properties make it valuable in alopecia, chronic wound, and skin aging research.
Cardiology: TB-500 has demonstrated significant cardioprotective effects in ischemia-reperfusion injury models. Research shows it reduces cardiomyocyte apoptosis, promotes cardiac progenitor cell migration to damaged areas, and attenuates fibrotic remodeling following myocardial infarction. Its ability to preserve cardiac function after ischemic events positions it as a key compound in cardiovascular repair and regeneration studies.
Immunology: As a derivative of Thymosin Beta-4, TB-500 is studied for its anti-inflammatory and immunomodulatory properties. Research demonstrates suppression of pro-inflammatory cytokines (IL-1β, TNF-α), reduction of neutrophil infiltration at injury sites, and modulation of macrophage polarization toward anti-inflammatory M2 phenotypes. These properties are relevant to autoimmune disease, transplant rejection, and chronic inflammation research.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.

Quality Assurance Standards

Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.

Certificate of Analysis

Latest COA for TB-500 (Capsules) — independently tested via HPLC and Mass Spectrometry.

COA-TB500-09-2025

Testing Methodology

Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.

• HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
• Mass Spectrometry — Validates molecular identity and correct sequence.
• Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
• Sterility — Microbial contamination testing per USP standards.