PT-141

Melanocortin Receptor Agonist (Bremelanotide)

CAS: 189691-06-3

Formula: C₅₀H₆₈N₁₄O₁₀

M.W.: 1025.1781 g/mol

Purity: 99%+ HPLC Verified

Ref No.: PT-0010VI

For Research Use Only (RUO)

Not for human or veterinary use.

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99%+ HPLC Verified Purity

PT-141

Name: PT-141
SKU: pt-141
Availability: InStock

Category

GH / Neuro / Misc

CAS Number

189691-06-3

Form Factor

Lyophilized Powder

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10 mg

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PT-141 (Bremelanotide) is a melanocortin receptor agonist acting on MC3R and MC4R in the CNS to modulate sexual arousal signaling. Unlike PDE5 inhibitors, it works through a central nervous system mechanism. It is FDA-approved (Vyleesi) for hypoactive sexual desire disorder in premenopausal women.

CAS Number

189691-06-3

Secondary CAS

32780-32-8

Purity

99%+ HPLC Verified

Molecular Formula

C₅₀H₆₈N₁₄O₁₀

Molar Mass

1025.1781 g/mol

Form Factor

Lyophilized Powder

Synonyms

Bremelanotide Vyleesi®

Sexual Medicine: PT-141 (Bremelanotide) is studied for its unique central nervous system mechanism of sexual arousal signaling, acting through melanocortin MC3R and MC4R receptors. Unlike PDE5 inhibitors that act peripherally, PT-141 modulates desire and arousal at the hypothalamic level. Research examines the neural circuitry of sexual arousal, dopaminergic pathway involvement, and the distinction between desire and physiological arousal mechanisms.
Neuropharmacology: PT-141 is studied as a melanocortin receptor pathway research tool. Its selective agonism at MC3R and MC4R provides insights into melanocortin signaling in sexual behavior, energy homeostasis, and stress response. Research examines receptor binding kinetics, downstream signaling cascades, and the tissue-specific expression patterns of melanocortin receptors in the CNS.
Reproductive Endocrinology: PT-141 is studied in the context of desire and arousal disorders, an area traditionally lacking pharmacological interventions. Research examines its efficacy across different etiologies of sexual dysfunction, including psychogenic, hormonal, and neurological causes. As the basis for FDA-approved Vyleesi, it provides validated clinical models for studying central nervous system-mediated sexual function.
Comparative Pharmacology: PT-141 is used in comparative studies examining CNS versus peripheral mechanisms of sexual function. Research contrasts its central melanocortin mechanism against the peripheral PDE5 inhibition of sildenafil-class drugs, investigating whether combination approaches or patient-specific pathway targeting can improve outcomes in sexual dysfunction research.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.