IGF-1 LR3
Long-Acting Insulin-Like Growth Factor
CAS: 946870-92-4
Formula: C400H625N111O115S9
M.W.: 9117.5099 g/mol
Purity: 99%+ HPLC Verified
Ref No.: IGF-0001VI
For Research Use Only (RUO)
Not for human or veterinary use.
IGF-1 LR3
Category
GH / Neuro / Misc Research
CAS Number
946870-92-4
Form Factor
Lyophilized Powder
In stock, ready to ship
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Products are shipped in lyophilized powder form.
IGF-1 LR3 is a synthetic IGF-1 analog with an arginine substitution and 13-amino-acid extension that dramatically reduces binding to IGF-binding proteins, extending its half-life from ~20 minutes to over 20 hours. It promotes cell proliferation, satellite cell activation, and neuronal survival across multiple tissue types.
Description
IGF-1 LR3 is a synthetic IGF-1 analog with an arginine substitution and 13-amino-acid extension that dramatically reduces binding to IGF-binding proteins, extending its half-life from ~20 minutes to over 20 hours. It promotes cell proliferation, satellite cell activation, and neuronal survival across multiple tissue types.Chemical Information
CAS Number
946870-92-4
Purity
99%+ HPLC Verified
Molecular Formula
C400H625N111O115S9
Molar Mass
9117.5099 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Muscle Biology: IGF-1 LR3 is studied for its potent effects on satellite cell activation, muscle protein synthesis, and skeletal muscle hypertrophy. The LR3 modification dramatically reduces IGF-binding protein affinity, extending its half-life from 20 minutes to over 20 hours and increasing tissue exposure to bioactive IGF-1 signaling. Research examines the dose-response relationship for muscle growth, fiber type effects, and the mechanisms of myoblast proliferation and differentiation.
- Neuroscience: IGF-1 LR3 is studied for its neuroprotective and neurodevelopmental effects, including promotion of neuronal survival, oligodendrocyte myelination, and synaptic plasticity. Research examines its potential for protecting against glutamate excitotoxicity, supporting axonal regeneration following injury, and enhancing cognitive function through IGF-1 receptor signaling in hippocampal and cortical circuits.
- Pharmacokinetics: IGF-1 LR3 is studied as a model for extended half-life growth factor analog optimization. Research examines how the 13-amino-acid N-terminal extension and Glu3→Arg substitution reduce IGFBP binding, the pharmacokinetic consequences of this modification, and the resulting changes in tissue distribution and receptor activation kinetics compared to native IGF-1.
- Cell Biology: IGF-1 LR3 is studied for its broad proliferative signaling effects including nitrogen retention, cell cycle progression, and anti-apoptotic signaling. Research examines the PI3K/Akt and MAPK/ERK pathways activated by IGF-1R engagement, the tissue-specific outcomes of sustained IGF-1 signaling, and the implications for regenerative medicine and cellular growth regulation research.
Laboratory Preparation Protocol
- 1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
- 2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
- 3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
- 4 Gently swirl (do not shake) the vial until the powder is fully dissolved and the solution appears clear, as shown in the vial image.
- 5 Label the vial with the reconstitution date and concentration.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Always note the reconstitution date on the vial label to track shelf life accurately.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
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Description
IGF-1 LR3 is a synthetic IGF-1 analog with an arginine substitution and 13-amino-acid extension that dramatically reduces binding to IGF-binding proteins, extending its half-life from ~20 minutes to over 20 hours. It promotes cell proliferation, satellite cell activation, and neuronal survival across multiple tissue types.Chemical Information
CAS Number
946870-92-4
Purity
99%+ HPLC Verified
Molecular Formula
C400H625N111O115S9
Molar Mass
9117.5099 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Muscle Biology: IGF-1 LR3 is studied for its potent effects on satellite cell activation, muscle protein synthesis, and skeletal muscle hypertrophy. The LR3 modification dramatically reduces IGF-binding protein affinity, extending its half-life from 20 minutes to over 20 hours and increasing tissue exposure to bioactive IGF-1 signaling. Research examines the dose-response relationship for muscle growth, fiber type effects, and the mechanisms of myoblast proliferation and differentiation.
- Neuroscience: IGF-1 LR3 is studied for its neuroprotective and neurodevelopmental effects, including promotion of neuronal survival, oligodendrocyte myelination, and synaptic plasticity. Research examines its potential for protecting against glutamate excitotoxicity, supporting axonal regeneration following injury, and enhancing cognitive function through IGF-1 receptor signaling in hippocampal and cortical circuits.
- Pharmacokinetics: IGF-1 LR3 is studied as a model for extended half-life growth factor analog optimization. Research examines how the 13-amino-acid N-terminal extension and Glu3→Arg substitution reduce IGFBP binding, the pharmacokinetic consequences of this modification, and the resulting changes in tissue distribution and receptor activation kinetics compared to native IGF-1.
- Cell Biology: IGF-1 LR3 is studied for its broad proliferative signaling effects including nitrogen retention, cell cycle progression, and anti-apoptotic signaling. Research examines the PI3K/Akt and MAPK/ERK pathways activated by IGF-1R engagement, the tissue-specific outcomes of sustained IGF-1 signaling, and the implications for regenerative medicine and cellular growth regulation research.
Laboratory Preparation Protocol
- 1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
- 2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
- 3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
- 4 Gently swirl (do not shake) the vial until the powder is fully dissolved and the solution appears clear, as shown in the vial image.
- 5 Label the vial with the reconstitution date and concentration.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Always note the reconstitution date on the vial label to track shelf life accurately.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
