GHK-Cu
Copper Tripeptide
CAS: 89030-95-5
Formula: C14H22CuN6O4
M.W.: 401.9105 g/mol
Purity: 99%+ HPLC Verified
Ref No.: GHK-0050VI
For Research Use Only (RUO)
Not for human or veterinary use.
GHK-Cu
Category
Tissue Repair / Regenerative Research
CAS Number
49557-75-7
Form Factor
Lyophilized Powder
In stock, ready to ship
Ships same day before 12pm PST
Products are shipped in lyophilized powder form.
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper-binding tripeptide first identified in human plasma in 1973. Its levels decline with age, correlating with diminished regenerative capacity. Genomic studies show it modulates over 4,000 human genes spanning collagen synthesis, antioxidant defense, and stem cell recruitment.
Description
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper-binding tripeptide first identified in human plasma in 1973. Its levels decline with age, correlating with diminished regenerative capacity. Genomic studies show it modulates over 4,000 human genes spanning collagen synthesis, antioxidant defense, and stem cell recruitment.Chemical Information
CAS Number
89030-95-5
Purity
99%+ HPLC Verified
Molecular Formula
C14H22CuN6O4
Molar Mass
401.9105 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Dermatology: GHK-Cu is one of the most extensively studied peptides in dermatological research, with over four decades of investigation into skin aging, wound healing, and scar remodeling. Studies demonstrate stimulation of collagen I, III, and V synthesis, increased elastin production, glycosaminoglycan accumulation, and enhanced fibroblast proliferation. Clinical studies confirm improvements in skin thickness, density, elasticity, and overall photoaging scores.
- Genomics: GHK-Cu has been the subject of landmark genomic studies revealing it modulates the expression of over 4,000 human genes — approximately one-third of the human genome. Gene Ontology analysis shows it upregulates genes associated with tissue repair, antioxidant defense, and stem cell function while suppressing genes linked to inflammation, fibrosis, and tissue destruction. This broad genomic influence makes it a model compound for gene-regulatory peptide research.
- Regenerative Medicine: In regenerative research, GHK-Cu is studied for its ability to recruit mesenchymal stem cells, activate tissue remodeling pathways, and reset gene expression patterns toward a healthier, more youthful phenotype. Research examines its effects on dermal, vascular, neural, and connective tissue regeneration, with implications for chronic wound management and age-related tissue deterioration.
- Cosmetic Science: GHK-Cu is a leading active ingredient in cosmetic science research for anti-aging formulation development. Studies compare topical, injectable, and systemic delivery methods for optimal skin rejuvenation outcomes. Research examines its synergistic effects with other anti-aging compounds and its ability to improve skin hydration, firmness, and clarity across different age groups and skin types.
- Oncology: Emerging oncological research examines GHK-Cu's ability to reset gene expression patterns in damaged cells toward a healthier phenotype. Studies investigate whether its broad genomic influence can suppress pro-metastatic gene networks, reduce cancer-associated inflammation, and modulate the tumor microenvironment. This represents a novel gene-regulatory approach to cancer prevention research.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for GHK-Cu — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
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Description
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring copper-binding tripeptide first identified in human plasma in 1973. Its levels decline with age, correlating with diminished regenerative capacity. Genomic studies show it modulates over 4,000 human genes spanning collagen synthesis, antioxidant defense, and stem cell recruitment.Chemical Information
CAS Number
89030-95-5
Purity
99%+ HPLC Verified
Molecular Formula
C14H22CuN6O4
Molar Mass
401.9105 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Dermatology: GHK-Cu is one of the most extensively studied peptides in dermatological research, with over four decades of investigation into skin aging, wound healing, and scar remodeling. Studies demonstrate stimulation of collagen I, III, and V synthesis, increased elastin production, glycosaminoglycan accumulation, and enhanced fibroblast proliferation. Clinical studies confirm improvements in skin thickness, density, elasticity, and overall photoaging scores.
- Genomics: GHK-Cu has been the subject of landmark genomic studies revealing it modulates the expression of over 4,000 human genes — approximately one-third of the human genome. Gene Ontology analysis shows it upregulates genes associated with tissue repair, antioxidant defense, and stem cell function while suppressing genes linked to inflammation, fibrosis, and tissue destruction. This broad genomic influence makes it a model compound for gene-regulatory peptide research.
- Regenerative Medicine: In regenerative research, GHK-Cu is studied for its ability to recruit mesenchymal stem cells, activate tissue remodeling pathways, and reset gene expression patterns toward a healthier, more youthful phenotype. Research examines its effects on dermal, vascular, neural, and connective tissue regeneration, with implications for chronic wound management and age-related tissue deterioration.
- Cosmetic Science: GHK-Cu is a leading active ingredient in cosmetic science research for anti-aging formulation development. Studies compare topical, injectable, and systemic delivery methods for optimal skin rejuvenation outcomes. Research examines its synergistic effects with other anti-aging compounds and its ability to improve skin hydration, firmness, and clarity across different age groups and skin types.
- Oncology: Emerging oncological research examines GHK-Cu's ability to reset gene expression patterns in damaged cells toward a healthier phenotype. Studies investigate whether its broad genomic influence can suppress pro-metastatic gene networks, reduce cancer-associated inflammation, and modulate the tumor microenvironment. This represents a novel gene-regulatory approach to cancer prevention research.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Quality Assurance Standards
Each production lot is subjected to rigorous analytical evaluation to meet pharmaceutical-grade specifications. Full testing results and procedural documentation are furnished through the accompanying Certificate of Analysis (COA) with every shipment.
Certificate of Analysis
Latest COA for GHK-Cu — independently tested via HPLC and Mass Spectrometry.
Testing Methodology
Every batch undergoes a multi-stage analytical pipeline before release. Results are compiled into the Certificate of Analysis (COA) included with each order.
- • HPLC — High-Performance Liquid Chromatography confirms peptide purity ≥98%.
- • Mass Spectrometry — Validates molecular identity and correct sequence.
- • Endotoxin (LAL) — Limulus Amebocyte Lysate assay ensures endotoxin levels are within safe limits.
- • Sterility — Microbial contamination testing per USP standards.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
