MK-677 (Capsules)

Growth Hormone Secretagogue (Ibutamoren)

CAS: 159752-10-0

Formula: C₂₇H₃₆N₄O₅S

M.W.: 528.6701 g/mol

Purity: 99%+ HPLC Verified

Ref No.:MK-0012TA

For Research Use Only (RUO)

Not for human or veterinary use.

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99%+ HPLC Verified Purity

MK-677 (Capsules)

Category

GH / Neuro / Misc Research

CAS Number

159752-10-0

Form Factor

Capsules

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MK-677 (Ibutamoren) is an orally active, non-peptide growth hormone secretagogue that mimics ghrelin at the GHS-R1a receptor. Clinical research shows sustained GH and IGF-1 elevation with daily oral dosing without pituitary desensitization, plus improved sleep quality, lean body mass, and bone mineral density.

CAS Number

159752-10-0

Purity

99%+ HPLC Verified

Molecular Formula

C₂₇H₃₆N₄O₅S

Molar Mass

528.6701 g/mol

Form Factor

Capsules

Synonyms

Ibutamoren Nutrobal L-163,191

Endocrinology: MK-677 (Ibutamoren) capsules are studied as an oral, non-peptide growth hormone secretagogue that mimics ghrelin at the GHS-R1a receptor. Research examines the unique property of sustained GH and IGF-1 elevation with daily oral dosing without pituitary desensitization — a significant advantage over injectable GH secretagogues. Studies investigate the mechanisms preventing tachyphylaxis and the long-term consequences of chronic oral GH axis stimulation.
Gerontology: MK-677 is studied in aging research for age-related sarcopenia and bone density decline. Research demonstrates improved lean body mass, increased bone mineral density, and enhanced nitrogen balance in elderly subjects during clinical trials. Studies examine whether chronic oral GH secretagogue use can prevent or reverse the progressive loss of muscle mass and skeletal integrity associated with aging.
Sleep Medicine: MK-677 is studied for its effects on sleep quality, with clinical data showing increased duration of REM sleep and improved overall sleep quality. Research examines the relationship between GH secretion patterns and sleep architecture, and whether MK-677's ghrelin receptor agonism directly influences sleep-promoting neural circuits independently of its GH-releasing effects.
Metabolism: MK-677 is studied for body composition optimization through chronic ghrelin receptor agonism. Research examines the balance between its anabolic effects (lean mass gain, bone density improvement) and its metabolic effects (appetite stimulation, potential insulin resistance with prolonged use). Studies investigate dosing strategies that maximize anabolic benefits while minimizing adverse metabolic consequences.

Reconstitution Protocol

1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall — do not spray directly onto the powder.
4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

Wear nitrile gloves and safety goggles when handling research compounds.
Work in a clean, controlled environment (laminar flow hood recommended).
Dispose of sharps and used materials in approved biohazard containers.
This product is for laboratory research use only (RUO) — not for human or veterinary use.