Melanotan-2
Melanocortin Receptor Agonist (MT-II)
CAS: 121062-08-6
Formula: C50H69N15O9
M.W.: 1024.1785 g/mol
Purity: 99%+ HPLC Verified
Ref No.: ML2-0010VI
For Research Use Only (RUO)
Not for human or veterinary use.
Melanotan-2
Category
GH / Neuro / Misc Research
CAS Number
121062-08-6
Form Factor
Lyophilized Powder
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Melanotan II is a cyclic heptapeptide α-MSH analog that non-selectively activates multiple melanocortin receptors (MC1R-MC5R), producing diverse effects including skin pigmentation, appetite modulation, and sexual arousal signaling. Its MC4R agonism led to the development of FDA-approved PT-141 (Bremelanotide).
Description
Melanotan II is a cyclic heptapeptide α-MSH analog that non-selectively activates multiple melanocortin receptors (MC1R-MC5R), producing diverse effects including skin pigmentation, appetite modulation, and sexual arousal signaling. Its MC4R agonism led to the development of FDA-approved PT-141 (Bremelanotide).Chemical Information
CAS Number
121062-08-6
Secondary CAS
192568-05-7
Purity
99%+ HPLC Verified
Molecular Formula
C50H69N15O9
Molar Mass
1024.1785 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Dermatology: Melanotan-2 is studied for melanocortin-mediated skin pigmentation through non-selective activation of MC1R-MC5R. Research examines the kinetics of tanning response induction, the uniformity of melanin distribution, and the histological changes in melanocyte density and activity. Studies also monitor existing nevi for morphological changes, contributing to melanocyte biology and skin cancer risk assessment research.
- Sexual Medicine: Melanotan-2's non-selective MC4R agonism produces sexual arousal effects that led to the development of PT-141 (Bremelanotide). Research continues to examine the melanocortin basis of sexual function, comparing MT-II's broader receptor activity profile against PT-141's more selective approach to understand the optimal receptor selectivity for sexual dysfunction therapy development.
- Metabolic Research: Melanotan-2 is studied for appetite suppression and lipolytic effects mediated through central melanocortin signaling. Research examines MC4R-dependent anorexic effects, changes in food preference and caloric intake, and the direct lipolytic activity observed in adipose tissue models. Studies investigate whether these metabolic effects can be separated from pigmentation and sexual function effects through receptor-selective analog design.
- Photobiology: Melanotan-2 is studied for its ability to induce protective tanning responses without UV exposure. Research examines the degree of photoprotection conferred by MT-II-induced melanin, the comparative UV damage between MT-II-tanned and UV-tanned skin, and the cellular mechanisms underlying pharmacological melanogenesis versus UV-induced melanogenesis.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
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Research Database
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Description
Melanotan II is a cyclic heptapeptide α-MSH analog that non-selectively activates multiple melanocortin receptors (MC1R-MC5R), producing diverse effects including skin pigmentation, appetite modulation, and sexual arousal signaling. Its MC4R agonism led to the development of FDA-approved PT-141 (Bremelanotide).Chemical Information
CAS Number
121062-08-6
Secondary CAS
192568-05-7
Purity
99%+ HPLC Verified
Molecular Formula
C50H69N15O9
Molar Mass
1024.1785 g/mol
Form Factor
Lyophilized Powder
Synonyms
Research Applications
- Dermatology: Melanotan-2 is studied for melanocortin-mediated skin pigmentation through non-selective activation of MC1R-MC5R. Research examines the kinetics of tanning response induction, the uniformity of melanin distribution, and the histological changes in melanocyte density and activity. Studies also monitor existing nevi for morphological changes, contributing to melanocyte biology and skin cancer risk assessment research.
- Sexual Medicine: Melanotan-2's non-selective MC4R agonism produces sexual arousal effects that led to the development of PT-141 (Bremelanotide). Research continues to examine the melanocortin basis of sexual function, comparing MT-II's broader receptor activity profile against PT-141's more selective approach to understand the optimal receptor selectivity for sexual dysfunction therapy development.
- Metabolic Research: Melanotan-2 is studied for appetite suppression and lipolytic effects mediated through central melanocortin signaling. Research examines MC4R-dependent anorexic effects, changes in food preference and caloric intake, and the direct lipolytic activity observed in adipose tissue models. Studies investigate whether these metabolic effects can be separated from pigmentation and sexual function effects through receptor-selective analog design.
- Photobiology: Melanotan-2 is studied for its ability to induce protective tanning responses without UV exposure. Research examines the degree of photoprotection conferred by MT-II-induced melanin, the comparative UV damage between MT-II-tanned and UV-tanned skin, and the cellular mechanisms underlying pharmacological melanogenesis versus UV-induced melanogenesis.
Storage Conditions
Unreconstituted
Store at -20°C to 4°C (freezer or refrigerator). Stable for 24+ months.
Reconstituted
Refrigerate at 2–8°C. Use within 30 days for optimal stability.
Avoid
Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25°C.
Safety & Compliance
- Wear nitrile gloves and safety goggles when handling research compounds.
- Work in a clean, controlled environment (laminar flow hood recommended).
- Dispose of sharps and used materials in approved biohazard containers.
- This product is for laboratory research use only (RUO) — not for human or veterinary use.
Learn More About Peptides
Explore our research library covering purity, synthesis, storage, solubility, and more.
Research Database
Browse peer-reviewed studies, clinical trials, and scientific sources behind our peptide resources.
