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Cagrilintide | GLP-1 (SG) (Blend)

Category

GLP / Metabolic

Form Factor

Lyophilized Powder

Cagrilintide

2.5 mg

5 mg

CAS: 1415456-99-3

GLP-1 (SG)

2.5 mg

5 mg

CAS: 910463-68-2

Cagrilintide

CAS

1415456-99-3

Formula

C194H312N54O59S2

Molar Mass

4425.1146 g/mol

GLP-1 (SG)

CAS

910463-68-2

Formula

C187H291N45O59

Molar Mass

4113.5751 g/mol

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This dual-agonist blend combines Cagrilintide (long-acting amylin analog) with GLP-1 (SG) (GLP-1 receptor agonist) for synergistic metabolic research. Clinical data from the CagriSema program demonstrates unprecedented weight reduction exceeding 25% when both pathways are activated simultaneously, surpassing either agent alone.

This dual-agonist blend combines Cagrilintide (long-acting amylin analog) with GLP-1 (SG) (GLP-1 receptor agonist) for synergistic metabolic research. Clinical data from the CagriSema program demonstrates unprecedented weight reduction exceeding 25% when both pathways are activated simultaneously, surpassing either agent alone.

Purity

99%+ HPLC Verified

Form Factor

Lyophilized Powder

Synonyms

CagriSema Cagrilintide / Semaglutide Amylin + GLP-1 Dual

Cagrilintide

2.5 mg

5 mg

CAS: 1415456-99-3

GLP-1 (SG)

2.5 mg

5 mg

CAS: 910463-68-2

Cagrilintide

CAS

1415456-99-3

Formula

C194H312N54O59S2

Molar Mass

4425.1146 g/mol

GLP-1 (SG)

CAS

910463-68-2

Formula

C187H291N45O59

Molar Mass

4113.5751 g/mol

  • Obesity & Metabolic Research: The Cagrilintide | GLP-1 (SG) blend represents a dual-agonist approach combining amylin and GLP-1 receptor activation for synergistic weight management research. Clinical data from the CagriSema program demonstrates unprecedented weight reduction exceeding 25% when both pathways are activated simultaneously. Research examines the complementary mechanisms of amylin-mediated satiety signaling and GLP-1-driven insulin sensitization, appetite suppression, and delayed gastric emptying.
  • Endocrinology: This combination is studied for its effects on the incretin-amylin hormonal axis and pancreatic beta-cell function. Research investigates how simultaneous amylin analog and GLP-1 receptor agonist administration modulates postprandial glucose excursions, insulin secretion dynamics, and glucagon suppression. Studies examine the potential for improved glycemic control beyond what either agent achieves independently, with implications for type 2 diabetes therapeutic development.
  • Pharmaceutical Sciences: The Cagrilintide | GLP-1 (SG) combination is studied as a model for multi-target peptide therapeutics. Research focuses on the pharmacokinetic interactions between the two peptides, optimal dosing ratios, reconstitution stability, and the formulation science of co-lyophilized peptide blends. Studies also examine the long-acting acylation technology that extends cagrilintide's half-life for weekly dosing compatibility with GLP-1 (SG).
  • Neuroscience of Appetite: This dual-agonist blend is investigated for its effects on central appetite regulation circuits. Research examines how combined amylin and GLP-1 receptor activation in the area postrema, nucleus tractus solitarius, and hypothalamic feeding centers produces enhanced satiety signaling compared to single-agent approaches. Studies map the neural pathways responsible for the synergistic reduction in food intake observed in preclinical and clinical models.

Reconstitution Protocol

  1. 1 Remove the flip-off cap and wipe the rubber stopper with an alcohol swab.
  2. 2 Using a sterile syringe, draw the desired volume of bacteriostatic water (BAC water).
  3. 3 Insert the needle into the vial at an angle and slowly dispense the water down the inside wall β€” do not spray directly onto the powder.
  4. 4 Gently swirl (do not shake) the vial until the powder is fully dissolved.
  5. 5 Label the vial with the reconstitution date and concentration.

Storage Conditions

Unreconstituted

Store at -20Β°C to 4Β°C (freezer or refrigerator). Stable for 24+ months.

Reconstituted

Refrigerate at 2–8Β°C. Use within 30 days for optimal stability.

Avoid

Repeated freeze-thaw cycles, direct sunlight, and temperatures above 25Β°C.

Always note the reconstitution date on the vial label to track shelf life accurately.

Safety & Compliance

  • Wear nitrile gloves and safety goggles when handling research compounds.
  • Work in a clean, controlled environment (laminar flow hood recommended).
  • Dispose of sharps and used materials in approved biohazard containers.
  • This product is for laboratory research use only (RUO) β€” not for human or veterinary use.

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